产品货号：
Z37735
中文名称：
Fascin/FSCN1抗体
英文名称：
Anti-Fascin/FSCN1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Fascin/FSCN1 Antibody |
| 指标别名 | 55kDa actin bundling protein;FAN1;Fascin;Fascin 1;Fascin;FSCN1;HSN;p55;Singed like protein;SNL |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,IP,FCM |
| 基因名称 | FSCN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Fascin Promotes cross-linkage of parallel actin filaments during the formation of cell protrusions (lamellipodia and filopodia),and therefore plays an important role in regulating cell migration.It has been reported that fascin may also regulate filopodia formation by a mechanism independent of its actin-bundling functions,though less is known about this mechanism of action. |
| 实际分子量 | 55KD |
| 成分 | Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Fascin is an actin cross-linking protein.The Fascin gene contains 5 exons and spans 7kb.It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates,including humans.Fascin (from the Latin for bundle) is spaced at 11 nanometre intervals along the filament.The bundles in cross section are seen to be hexagonally packed,and the longitudinal spacing is compatible with a model where fascin cross-links at alternating 4 and 5 actins.It is calcium insensitive and monomeric.Fascin binds beta-catenin,and colocalizes with it at the leading edges and borders of epithelial and endothelial cells.The role of Fascin in regulating cytoskeletal structures for the maintenance of cell adhesion,coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective.Abnormal fascin expression or function has been implicated in breast cancer,colon cancer,esophageal squamous cell carcinoma,gallbladder cancer and prostate cancer. |
| Uniprot ID | Q16658 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100ICC/IF Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 Flow cytometry (FCM) 1:20 |
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